Comment: "A proteome-wide atlas of drug mechanism of action"
It's been a while, but I found a very interesting paper that I want to comment. Proteomics is an invaluable tool for unlocking the secrets of compound polypharmacology: by quantifying the protein expression changes caused by different compounds, researchers can gain valuable insight into compound interactions at the cellular level. Proteomics in application to the understanding of compound polypharmacology is relatively well established : there are tons and tons of publications on this topic about single compounds or some SAR exploration with 10s of compounds max… and now this goldmine was published – “ A proteome-wide atlas of drug mechanism of action ”. 875 compounds, 875 proteomics profile after 24h treatment (in duplicate) on ~9000 proteins in HCT116 cell line . To be honest, nothing radically new was done in this paper, but the robustness, richness, and accessibility of data that were generated in this paper are, in my opinion, unprecedented. Articles like this have a globa...